Thrice-weekly temocillin administered after each dialysis session is appropriate for the treatment of serious Gram-negative infections in haemodialysis patients

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Thrice-weekly temocillin administered after each dialysis session is appropriate for the treatment of serious Gram-negative infections in haemodialysis patients.

In patients with end-stage renal disease (ESRD) treated with intermittent haemodialysis, a limited number of antibiotics have been studied for their suitability for parenteral administration after dialysis sessions only in a thrice-weekly regimen. Temocillin is a β-lactam antibiotic with a long half-live and enhanced activity against most Gram-negative bacteria, including extended-spectrum β-la...

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Thrice weekly warfarin administration in haemodialysis patients.

BACKGROUND Medication adherence in haemodialysis patients is often challenging due to a high pill burden, complex and dynamic medication regimens and limited patient self-interest in care. The purpose of this study was to investigate the time within target INR and safety profile of thrice weekly warfarin administration in haemodialysis patients with a clinical indication for anticoagulation and...

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The results of an 8 h thrice weekly haemodialysis schedule.

The standard dialysis time is 8 h, three sessions per week. The original long haemodialysis (HD) technique has Cuprophan artificial kidneys are used. The 1 m2 Kiil dialysers been maintained unchanged since the opening of the initially used for all patients have been progressively replaced Tassin Unit 28 years ago [1]. This technique provides by flat-plate or hollow-fibre Cuprophane disposable d...

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Frequent use of aminoglycoside antibiotics in the treatment of serious Gram-negative infections

Frequent use of aminoglycoside antibiotics in the treatment of serious Gram-negative infections has been accompanied by the emergence of multiple drug-resistant strains of bacteria carrying R-factors. This has stimulated the study of resistance mechanisms and mechanisms for circumventing the drug inactivation caused by resistant bacteria. Thus, aminoglycoside antibiotics have been chemically mo...

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Gram-negative bacteraemia in haemodialysis.

BACKGROUND Patients on renal replacement therapy experience higher rates of morbidity and mortality, infection being the second commonest cause of death. In our haemodialysis population, we identify the pathogens, sensitivity patterns, sources of infection and outcomes of Gram-negative bacteraemia. METHODS Data from the NHS Greater Glasgow & Clyde and NHS Forth Valley haemodialysis population...

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ژورنال

عنوان ژورنال: International Journal of Antimicrobial Agents

سال: 2015

ISSN: 0924-8579

DOI: 10.1016/j.ijantimicag.2015.09.005